Cardil CR Adverse Reactions

The most common adverse effects of diltiazem include headache, dizziness, AV block (may be of 1st-, 2nd- or 3rd-degree; bundle branch block may occur), palpitations, peripheral oedema, flushing of face, nausea, constipation, dyspepsia, gastric pain, malaise, erythema and pruritus.
Other adverse effects of diltiazem include thrombocytopenia, leukopenia, weight gain, anorexia, nervousness, insomnia, mood changes (including depression), smell and taste disturbances, extrapyramidal syndrome, bradycardia, sinus arrest, aggravated angina pectoris, sinoatrial block, congestive heart failure, orthostatic hypotension, vasculitis (including leukocytoclastic vasculitis), vomiting, diarrhoea, dryness of mouth and throat, gingival hyperplasia, hepatic enzymes increased [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP)], hepatitis, urticaria, rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity reactions, exfoliative dermatitis, lupus erythematosus, acute generalised exanthematous pustulosis (AGEP), gynecomastia and polyuria.